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MedTech Outlook | Tuesday, January 04, 2022
COVID-19-positive outpatients are at an increased risk of neurodegenerative disorders compared with individuals who tested negative for the virus.
FREMONT, CA: Patients who tested positive for COVID-19 had a greater chance of developing Alzheimer's disease, Parkinson's disease, and ischemic stroke. The study examined the health records of more than half of the Danish population. 43,375 out of the 919,731 participants who tested positive for COVID-19 in the study had a 3.5 times higher risk of Alzheimer's disease, a 2.6 times higher risk of Parkinson's disease, a 2.7 times higher risk of an ischemic stroke, and 4.8 times higher risk of an intracerebral haemorrhage (bleeding in the brain). The authors also underlined the consequences of the scientific focus on long-term sequelae after COVID-19, even if neuroinflammation may speed up the development of neurodegenerative illnesses. Between February 2020 and November 2021, in and out-patients in Denmark, as well as influenza patients from the equivalent pre-pandemic period, were examined for the study. Results were stratified for hospitalisation status, age, sex, and comorbidities after statistical methods were applied to compute relative risk.
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The exact form and course of COVID-19's impacts on neurological illnesses are still unknown more than two years after the COVID-19 pandemic began, according to lead author Dr Pardis Zarifkar of the Department of Neurology at Rigshospitalet in Copenhagen, Denmark. Although previous research has shown a relationship with neurological syndromes, it is still unclear whether COVID-19 is unique from other respiratory illnesses and whether it affects the frequency of particular neurological diseases. However, the elevated risk of the majority of neurological diseases was no greater in COVID-19-positive patients than in individuals with influenza or other respiratory illness diagnoses. In comparison to patients with the flu and bacterial pneumonia who were over 80 years old, COVID-19 patients did have a 1.7-fold higher chance of having an ischemic stroke. Post COVID-19, influenza, or pneumonia, the prevalence of other neurological diseases such as multiple sclerosis, myasthenia gravis, Guillain-Barré syndrome, and narcolepsy did not rise. Dr Pardis Zarifkar continued that they found evidence supporting an increased likelihood of diagnosis with neurodegenerative and cerebrovascular illnesses in COVID-19 positive patients compared to COVID-negative patients, which must be confirmed or disproved shortly by sizable registry studies. Fortunately, the majority of neurological problems, except for ischemic stroke, do not seem to occur more frequently after COVID-19 than following influenza or community-acquired bacterial pneumonia. These results will advance scientific knowledge of COVID-19's long-term health effects and the part that infections play in stroke and neurological illnesses.
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