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MedTech Outlook | Wednesday, October 19, 2022
Sophisticated drug delivery methods for targeted and regulated release of new compounds in tissues and cells help to maximize patient benefits.
FREMONT, CA: From the initial stage of drug discovery to clinical trials, delivering potential new medications to their targets optimally for both the drug and the patient is essential. The prospective novel medicines differ from traditional small and existing large molecules, which target the cell surface or are administered without a molecular-targeting method. Scientists aim to remove barriers between the most promising new medication candidates and their tissue and cell targets. They're also researching ways to deliver oral versions of biological medications over the intestinal wall, evading generations of drug designers.
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Cell-targeted delivery: to access previously inaccessible targets in specific cells. Researchers are interested in using mRNA to create therapeutics directly in the cell, transforming cells into "biological factories" that produce therapeutic proteins, antigens, or antibodies to heal damaged organs and tissues.
Tissue-specific delivery: to reach therapeutic concentrations of medications at their targets while minimizing unwanted side effects. They are exploring a variety of formulations and methods, such as nanoparticles equipped with the appropriate targeting elements, such as antibodies, to create more well-tolerated drugs with the potential to reduce adverse effects and improve patient adherence.
Controlled release: For eliminating the need for frequent doses, thereby simplifying treatment and improving the patient's experience. They employ a variety of polymer, silica, and other tiny particles, as well as in situ gel and liquid crystal formulations, to increase the half-life of drugs and maximize the time they remain at their target.
Alternative modes of administration: To simplify the administration of biologics, they are developing oral solutions with the potential to improve patient outcomes. Researchers aim to protect oral biologics from degradation in the stomach and intestines and to enhance their absorption from the intestines into the bloodstream. To do this, they are custom-manufacturing synthetic peptides that are stable in the stomach environment for oral administration.
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