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MedTech Outlook | Monday, September 26, 2022
New technologies are emerging in wound healing and regeneration, generating effective results.
FREMONT, CA: Although skin wounds are not usually regarded as a serious issue, diseases can cause or contribute to the severity of a wound, requiring the intervention of technologies for adequate healing. Malnutrition, stress, and metabolic syndrome all predispose patients to chronic wounds and necessitate a disruption to hasten the healing process.
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Medical professionals have started utilising innovations such as biological dressings and negative pressure therapy for wound healing. However, several promising technologies will play a vital role in future clinical pathways.
3D-printed Stem Cells
The stem cell's ability to metamorphose into any type in the body is well documented and is the foundation for several treatments, including faster wound healing. However, 3D printers can implant stem cells onto wounds embedded in a skin graft made of bio link to help tissue heal. This technique's different use cases and applications are yet to be discovered, as recent research focused only on supporting devices for thickness burns.
Natural bioinks can mimic the 3D microenvironment structure of native skin tissue and promote cell adhesion, migration, mobility, and proliferation. Researchers anticipate 3D printers' introduction into clinical settings within the next five years.
Collagen-based Wound Dressing
Before the emergence of skin grafts, dressing was the method to cover wounds. The treatment depended on the severity, and advanced dressing promoted faster recovery. Regardless of the different materials used to make these dressings, current solutions cannot create antibacterial barriers and facilitate efficient healing simultaneously.
The recent healing and antimicrobial property discoveries of human collagen VI resulted in the development of a product capable of improving wound management. Companies seek to address this unmet wound management challenge with their new bioactive wound dressing solutions, accelerating wound healing and simultaneously presenting clear antibacterial effects.
Fluorescence Point-of-care Imaging
The Fluorescence point-of-care imaging diagnostic tool allows clinicians to receive an accurate picture of bacteria quantity and virulence to customise treatment plans individually instead of treating the wound directly. A study using fluorescence imaging in patients with diabetic foot ulcers found that fluorescence point-of-care imaging increased the number of diabetic foot ulcer wounds healed by 23 per cent within 12 weeks. Implementing fluorescence imaging associates a decrease of 49 per cent in the prescription of antimicrobial dressing and 33 per cent in antibiotic prescriptions.
Bacteria-killing Lasers
The skin is a protective barrier to bacterial invasion, but a wound creates an entry point for bacteria to invade and reach the deeper layers of it. This can form biofilms that resist treatments applied to heal wounds and continue to survive, thereby requiring the removal of this bacteria.
Wound debridement, killing bacteria and removing necrotic (dead) tissue, is the primary step in healing serious wounds. Current procedures include surgical intervention and advanced dressings, applying enzymes to remove wound debris. Companies are working to commercialise a hand-held laser operated by a single health professional to kill the biofilm-producing bacteria. This killing of biofilm-producing bacteria in chronic wounds prevents amputations and unnecessary use of antibiotics.
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