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MedTech Outlook | Friday, June 25, 2021
MSCs offer a lot of therapeutic potential in a lot of different diseases. They have a high regenerative capacity, which could be useful in wound healing or post-infarct tissue regeneration.
FREMONT, CA: Researchers from one institute created a microneedle patch to transfer Mesenchymal Stem Cells (MSCs) into the skin. MSCs can survive in the gelatin matrix of biodegradable needles. When the patch is removed from the skin, the needles detach from the patch and remain within the tissue. The needles' hard outer shell deteriorates with time, allowing the cells within to produce therapeutic benefits on the surrounding tissue.
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MSCs offer a lot of therapeutic potential in a lot of different diseases. They have a high regenerative capacity, which could be useful in wound healing or post-infarct tissue regeneration. However, getting these cells to the treatment site and maintaining them alive and well has proven to be a significant difficulty and a stumbling block to realizing their full therapeutic potential. In answer to this problem, scientists have created a wide range of biomaterial delivery devices. This current method is a little different, as it aims to distribute and keep MSCs in superficial tissues with potential wound healing applications.
In this latest study, the MSCs are embodied in a cross-linked gelatin matrix that endorses cell survival and therapeutic function. The soft matrix is enclosed in a hard, biodegradable shell that serves as the needle's surface. When the patch is put to the skin, the needles penetrate the tissue. The needles detach from the patch and remain implanted in the tissue once it is removed. Over time, the hard-outer shell breaks down, allowing the cells contained within to affect the surrounding tissue. The technique has been tested in a rodent wound healing model, and the researchers discovered that a patch containing MSCs enhanced wound healing and skin renewal.
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In the future, detachable hybrid microneedle depots could be rapidly fabricated in clinical laboratories shortly before use, applied to treat skin injuries, and investigated more broadly as treatments for a variety of other disorders, including melanoma and other dermatological disorders that could benefit from MSC cells' power. The notion could be applied to more personalized gadget approaches that use patient-derived cells.
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